Miglitol

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1.What is the Miglitol ?

white to light yellow crystal powde

Miglitol was introduced in Germany as an auxiliary treatment for non-insulin dependent diabetes (NIDDM). A simple two-step synthesis of Miglitol consists of converting 6-desoxy-6-aminosorbose into desoxynojirimycin by reductive cyclization, then selectively hydroxyethylating the cyclic nitrogen. Miglitol is a short-acting intestinal alpha-D-glucosidase inhibitor, reducing postprandial glucose excursions by helping to delay absorption of complex carbohydrates. Acarbose and voglibose are the previous compounds marketed in this class. At low doses, orally administered miglitol was shown to be rapidly and completely absorbed then removed by renal excretion.

2.What is the CAS number for Miglitol ?

The CAS number of Miglitol is 72432-03-2.

3.What are another words for Miglitol ?

Synonyms?for?Miglitol 72432-03-2:3,4,5-Piperidinetriol,1-(2-hydroxyethyl)-2-(hydroxymethyl)-, [2R-(2a,3b,4a,5b)]-;BAY 1099;BAY-m 1099;Diastabol;Glyset;3,4,5-Piperidinetriol,1-(2-hydroxyethyl)-2-(hydroxymethyl)-, (2R,3R,4R,5S)-;

4.What is Miglitol (72432-03-2) used for?

antibacterial

Miglitol [Glyset] is the second alpha-glucosidase inhibitor approved in the United States. Like acarbose, miglitol delays conversion of oligosaccharides and complex carbohydrates to glucose and other monosaccharides, and thereby reduces the postprandial rise in blood glucose. In clinical trials, the drug was especially effective among Latinos and African Americans. Hypoglycemia does not occur with miglitol monotherapy, but may occur if the drug is combined with insulin or a sulfonylurea. Like acarbose, miglitol causes flatulence, abdominal discomfort, and other GI effects. In contrast to acarbose, miglitol has not been associated with liver dysfunction. As with acarbose therapy, oral sucrose cannot be used to treat hypoglycemia. Rather, oral glucose must be given. Miglitol is available in 25-, 50-, and 100-mg tablets. The initial dosage is 25 mg 3 times daily before meals. The maintenance dosage is 50 or 100 mg 3 times a day.

InChI:InChI=1/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5?,6-,7?,8-/m1/s1

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