3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
- CasNo:425637-18-9
Product Description
Quality products?make an important contribution to long-term revenue and profitability. Factory Supply Industrial Grade 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione 425637-18-9 with Best Price
1.What is the 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione ?
Sotrastaurin is an protein kinase C inhibitor that modulates migration and superoxide anion production by human neutrophils in vitro.
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![2-[2-(4-methyl-piperazin-1-yl)-quinazolin-4-yl]-acetamide](/upload/2026/11/ed6014ff65654937b0910cfca61de200_a015f4b5-6f04-473a-91aa-9e2510452e96.png)
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425638-73-9
2-[2-(4-methyl-piperazin-1-yl)-quinazolin-4-yl]-acetamide
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425637-18-9
sotrastaurin
| Conditions | Yield |
|---|---|
|
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 - 20 ℃;
|
47%
|
|
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 - 20 ℃;
Inert atmosphere;
|
47%
|
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425638-74-0
2-(2-chloroquinazolin-4-yl)acetamide
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425637-18-9
sotrastaurin
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1: 1-methyl-pyrrolidin-2-one / 0.75 h / 50 °C / Inert atmosphere
2: potassium tert
-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
With
potassium tert-butylate;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one;
|
2.What is the CAS number for 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione ?
The CAS number of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione is 425637-18-9.
More information of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione 425637-18-9 are:
|
CAS?Number |
425637-18-9 |
|
Density |
1.407 g/cm3 |
|
PSA |
97.71000 |
|
LogP |
2.70890 |
|
Pka |
7.39±0.60(Predicted) |
3.What are another words for 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione ?
Synonyms?for?3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione 425637-18-9:3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione;AEB071;UNII-7I279E1NZ8;1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-(2-(4-methyl-1-piperazinyl)-4-quinazolinyl)-;
4.What is the molecular formula of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione?
The chemical formula of ?3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione is?C25H22N6O2 which containing 25 Carbon atoms,22 Hydrogen atoms,6 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of??3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione?is 438.48118.
5.What is 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (425637-18-9) used for?
Sotrastaurin (AEB071) is a potent and selective pan-PKC inhibitor, most potent against PKCθ with Ki of 0.22 nM in a cell-free assay; no activity against PKCζ.
Relevant articles related to 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione:
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Article |
Source |
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Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4- yl]-pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes |
Wagner, Jürgen,Von Matt, Peter,Sedrani, Richard,Albert, Rainer,Cooke, Nigel,Ehrhardt, Claus,Geiser, Martin,Rummel, Gabriele,Stark, Wilhelm,Strauss, Andre,Cowan-Jacob, Sandra W.,Beerli, Christian,Weckbecker, Gisbert,Evenou, Jean-Pierre,Zenke, Gerhard,Cottens, Sylvain supporting information; experimental part, p. 6193 - 6196 (2010/04/02) |
6.Buy 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione with the best price .
Qinhuangdao Bright Chemical Co.,Ltd is a quality supplier of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione 425637-18-9.