4-Nitro-2,3-lutidine-N-oxide
- CasNo:37699-43-7
Product Description
Factory Sells Best Quality 4-Nitro-2,3-lutidine-N-oxide 37699-43-7 with USP
- Molecular Formula: C7H8N2O3
- Molecular Weight: 168.152
- Vapor Pressure: 2.4E-06mmHg at 25°C
- Melting Point: 94-98 °C(lit.)
- Refractive Index: 1.573
- Boiling Point: 403.3 °C at 760 mmHg
- PKA: -1.03±0.10(Predicted)
- Flash Point: 197.7 °C
- PSA： 71.28000
- Density: 1.3 g/cm3
- LogP: 2.16330
4-Nitro-2,3-lutidine-N-oxide(Cas 37699-43-7) Usage
|
General Description |
4-Nitro-2,3-lutidine N-oxide can undergo reduction in the presence of Titanium(III) chloride in 50% aqueous acetonitrile. N-hydroxylamine is formed as a by-product during the reduction reaction. |
InChI:InChI=1/C7H8N2O3/c1-5-6(2)8(10)4-3-7(5)9(11)12/h3-4H,1-2H3
37699-43-7 Relevant articles
INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF
-
Page/Page column 122, (2018/04/20)
The present disclosure provides compound...
A 2, 3 - dimethyl -4 - nitro pyridine - N - oxide synthesis method
-
Paragraph 0013; 0018-0027, (2017/04/29)
The invention discloses a synthesis meth...
CXCR4 INHIBITORS AND USES THEREOF
-
Paragraph 00450, (2018/04/11)
The present invention provides compounds...
Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase
Lee, Won-Gil,Frey, Kathleen M.,Gallardo-Macias, Ricardo,Spasov, Krasimir A.,Chan, Albert H.,Anderson, Karen S.,Jorgensen, William L.
, p. 4824 - 4827 (2015/10/28)
Non-nucleoside inhibitors of HIV-1 rever...
37699-43-7 Process route
-
-
22710-07-2,166521-76-2
2,3-dimethylpyridine 1-oxide
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-
37699-43-7
2,3-dimethyl-4-nitropyridine N-oxide
| Conditions | Yield |
|---|---|
|
With
potassium nitrite; sulfuric acid;
at -10 - 85 ℃;
for 2h;
Temperature;
Green chemistry;
|
92.9%
|
|
With
sulfuric acid; nitric acid;
at 100 ℃;
for 5h;
|
78%
|
|
With
sulfuric acid; nitric acid;
at 95 ℃;
for 20h;
|
53%
|
|
With
sulfuric acid; nitric acid;
at 95 ℃;
|
|
|
With
sulfuric acid; potassium nitrate;
In
dichloromethane;
at -10 - 85 ℃;
for 3 - 4h;
|
80 - 82 %Chromat.
|
|
With
nitric acid;
In
sulfuric acid;
|
|
|
With
nitric acid;
In
conc. sulphuric acid;
|
|
|
With
sodium hydroxide;
In
(2S)-N-methyl-1-phenylpropan-2-amine hydrate; diethyl ether; dichloromethane; sulfuric acid;
|
|
|
With
sulfuric acid; nitric acid;
for 3.5h;
Heating / reflux;
|
|
|
With
sulfuric acid; nitric acid;
at 90 ℃;
for 24h;
|
|
|
With
sulfuric acid; nitric acid;
at 95 ℃;
|
|
|
With
sulfuric acid; nitric acid;
In
water;
at 95 ℃;
for 5h;
|
|
|
With
nitric acid;
|
-
-
5470-66-6
2-methyl-4-nitropyridine N-oxide
-
-
37699-43-7
2,3-dimethyl-4-nitropyridine N-oxide
| Conditions | Yield |
|---|---|
|
2-methyl-4-nitropyridine N-oxide; methylmagnesium halide;
In
tetrahydrofuran;
at -60 ℃;
Inert atmosphere;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran;
at -60 - 20 ℃;
regioselective reaction;
Inert atmosphere;
|
47%
|
37699-43-7 Upstream products
-
22710-07-2
2,3-dimethylpyridine 1-oxide
-
75-09-2
dichloromethane
-
497-19-8
sodium carbonate
-
5470-66-6
2-methyl-4-nitropyridine N-oxide
37699-43-7 Downstream products
-
103577-61-3
2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide
-
122475-57-4
4-amino-2,3-dimethylpyridine
-
68707-69-7
2,3-dimethyl-4-nitropyridine
-
59886-90-7
4-chloro-2,3-dimethylpyridine-N-oxide