ecteinascidin 743
- CasNo:114899-77-3
Product Description
High Quality Chinese Factory supply 114899-77-3 ecteinascidin 743
- Molecular Formula: C39H43N3O11S
- Molecular Weight: 761.85
- PKA: 9.73±0.40(Predicted)
- PSA： 194.02000
- Density: 1.53g/cm3
- LogP: 3.61780
114899-77-3 Relevant articles
A Concise and Practical Semisynthesis of Ecteinascidin 743 and (–)-Jorumycin
Xu, Shanghu,Wang, Guan,Zhu, Jinjin,Shen, Chuang,Yang, Zhezhou,Yu, Jun,Li, Zhong,Lin, Tanghuan,Sun, Xun,Zhang, Fuli
, p. 975 - 983 (2017)
Ecteinascidin 743 is an antitumor drug u...
Ecteinascidins 770 and 786 from the Thai tunicate Ecteinascidia thurstoni
Suwanborirux, Khanit,Charupant, Kornvika,Amnuoypol, Surattana,Pummangura, Sunibhond,Kubo, Akinori,Saito, Naoki
, p. 935 - 937 (2002)
Ecteinascidins 770 (1b) and 786 (3b) wer...
A Scalable Total Synthesis of the Antitumor Agents Et-743 and Lurbinectedin
He, Weiming,Zhang, Zhigao,Ma, Dawei
, p. 3972 - 3975 (2019)
An efficient and scalable approach is de...
PREPARATION METHOD FOR ECTEINASCIDIN COMPOUND AND INTERMEDIATE THEREOF
-
Paragraph 0111-0113, (2021/11/20)
The present invention provides a method ...
IMPROVED PROCESS FOR THE PREPARATON OF PURE (1'R,6R,6aR,7R,13S,14S,16R)-5-(ACETYLOXY)-3',4',6,6a,7,13,14,16-OCTAHYDRO-6',8,14-TRIHYDROXY-7',9-DIMETHOXY-4,10,23-TRIMETHYLSPIRO[6,16-(EPITHIOPROPANOXYMETH ANO)-7,13-IMINO-12H-1,3-DIOXOLO[7,8]ISOQUINO[3,2-b][3]BENZAZOCINE-20,1'(2'H)-ISOQUINOLIN]-19-ONE POLYMORPH THERE OF
-
Page/Page column 16; 21-22; 23, (2021/01/23)
The present invention provides pure (1'R...
PROCESS FOR THE PREPARATION OF ECTEINASCIDIN DERIVATIVE AND ITS INTERMEDIATE
-
Page/Page column 15-16; 19, (2020/06/10)
The present invention relates to an impr...
Preparation of natural product Trabectedin
-
Paragraph 0301-0305, (2019/07/04)
The invention provides a preparation met...
114899-77-3 Process route
-
![(1'R,6R,6aR,7R,13S,14R,16R)-5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile](/upload/2026/10/44c82cddb6224f56bfaf1373303d5e30_eb8af295-1d63-4b0e-a7cf-3b7145cb9a11.png)
-
114899-80-8
(1'R,6R,6aR,7R,13S,14R,16R)-5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile
-
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114899-77-3
ecteinascidin 743
| Conditions | Yield |
|---|---|
|
With
silver nitrate;
In
water; acetonitrile;
at 20 ℃;
for 11h;
|
96.9%
|
|
With
silver nitrate;
In
water; acetonitrile;
at 20 ℃;
for 24h;
Inert atmosphere;
|
95%
|
|
With
water; silver nitrate;
In
acetonitrile;
at 20 - 25 ℃;
for 2h;
Inert atmosphere;
Darkness;
|
95.1%
|
|
With
water; copper(l) chloride;
In
tetrahydrofuran;
at 23 ℃;
for 24h;
Inert atmosphere;
Darkness;
|
94%
|
|
With
silver nitrate;
In
water; acetonitrile;
at 20 ℃;
for 17h;
|
93%
|
|
With
silver nitrate;
In
water; acetonitrile;
at 25 ℃;
for 24h;
Inert atmosphere;
|
93%
|
|
With
silver nitrate;
In
acetonitrile;
at 23 ℃;
for 19h;
|
92%
|
|
With
silver nitrate;
In
water; acetonitrile;
|
88%
|
|
With
silver nitrate;
In
acetonitrile;
at 23 ℃;
for 11h;
|
|
|
With
silver nitrate;
In
water; acetonitrile;
at 20 ℃;
for 17h;
|
|
|
With
water; silver nitrate;
In
acetonitrile;
|
|
|
With
water; silver nitrate;
In
acetonitrile;
|
|
|
With
silver nitrate;
In
water; acetonitrile;
at 20 ℃;
|
|
|
With
silver nitrate;
In
water; acetonitrile;
at 20 - 25 ℃;
for 16h;
Temperature;
|
2.2 g
|
-
![(1'R,6R,6aR,7R,13S,14R,16R)-5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6'-hydroxy-7',9-dimethoxy-8-(methoxymethoxy)-4,10,23-trimethyl-19-oxo-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile](/upload/2026/10/1f39069ba287476eb1d945f746379565_497ee4b6-a621-4c66-943c-06590eb9229b.png)
-
203922-37-6
(1'R,6R,6aR,7R,13S,14R,16R)-5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6'-hydroxy-7',9-dimethoxy-8-(methoxymethoxy)-4,10,23-trimethyl-19-oxo-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile
-
-
114899-77-3
ecteinascidin 743
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1: aq. CF3
COOH / tetrahydrofuran / 9 h / 23 °C
2: aq. AgNO3
/ acetonitrile / 11 h / 23 °C
With
silver nitrate; trifluoroacetic acid;
In
tetrahydrofuran; acetonitrile;
|
|
|
(1'R,6R,6aR,7R,13S,14R,16R)-5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6'-hydroxy-7',9-dimethoxy-8-(methoxymethoxy)-4,10,23-trimethyl-19-oxo-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile;
With
trifluoroacetic acid;
In
tetrahydrofuran; water;
at 20 - 25 ℃;
for 16h;
With
silver nitrate;
In
water; acetonitrile;
at 20 - 25 ℃;
for 18h;
Reagent/catalyst;
Solvent;
|
114899-77-3 Upstream products
-
114899-80-8
(1'R,6R,6aR,7R,13S,14R,16R)-5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile
-
3213-30-7
5-(2-amino-ethyl)-2-methoxy-phenol
-
874758-51-7
ethyl 2-bromo-2-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)acetate
-
874758-55-1
ethyl 2-hydroxy-2-(6-(methoxymethoxy)-7-methylbenzo[d][1,3]dioxol-4-yl)acetate
114899-77-3 Downstream products
-
114899-80-8
ecteinascidin 770