NVP-BEZ 235
- CasNo:915019-65-7
Product Description
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1.What is the NVP-BEZ 235 ?
NVP-BEZ235 (915019-65-7) is a dual PI3K and mTOR kinase inhibitor.1?It inhibits VEGF-induced proliferation and angiogenesis.2?Reverses lapatinib resistance.3?It induces G1 arrest and reduces cyclin D1 expression in melanoma cells with negligible apoptosis.4?NVP-BEZ235 inhibits the growth of cancer cells with activating PI3K mutations.5?The ability of NVP-BEZ235 to inhibit PI3K has come into question. This study also shows it to be a potent inhibitor of PRKDC (IC50 = 29 nM), ATM (IC50 = 13 nM), and ATR (IC50 = 8 nM).6?Active in vivo.
Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.[Cayman Chemical]
2.What is the CAS number for NVP-BEZ 235 ?
The CAS number of NVP-BEZ 235 is 915019-65-7.
More information of NVP-BEZ 235 915019-65-7 are:
|
CAS?Number |
915019-65-7 |
|
Density |
1.299 g/cm3 |
|
Melting Point |
288-289°C |
|
Boiling Point |
701.025 °C at 760 mmHg |
|
Flash Point |
377.767 °C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.705 |
|
PSA |
76.50000 |
|
LogP |
4.36208 |
|
Pka |
6.41±0.20(Predicted) |
3.What is the molecular formula of NVP-BEZ 235 ?
The chemical formula of?NVP-BEZ 235 is C30 H23 N5 O which containing 30 Carbon atoms,23 Hydrogen atoms,5 Nitrogen atoms and 1 Oxygen atoms,and the molecular weight, and the molecular weight of NVP-BEZ 235 is 469.546
4.What is NVP-BEZ 235(915019-65-7)used for?
NVP-BEZ235 (915019-65-7) is a dual PI3K and mTOR kinase inhibitor.1?It inhibits VEGF-induced proliferation and angiogenesis.2?Reverses lapatinib resistance.3?It induces G1 arrest and reduces cyclin D1 expression in melanoma cells with negligible apoptosis.4?NVP-BEZ235 inhibits the growth of cancer cells with activating PI3K mutations.5?The ability of NVP-BEZ235 to inhibit PI3K has come into question. This study also shows it to be a potent inhibitor of PRKDC (IC50 = 29 nM), ATM (IC50 = 13 nM), and ATR (IC50 = 8 nM).6?Active in vivo.
InChI:InChI=1/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
Relevant articles related to NVP-BEZ 235:
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Article |
Source |
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Development of a Robust Synthesis of Dactolisib on a Commercial Manufacturing Scale |
Baenziger, Markus,Pachinger, Werner,Stauffer, Frédéric,Zaugg, Werner , p. 1908 - 1917 (2019/09/30) |
5.99% Purity Commercial production NVP-BEZ 235 915019-65-7 with Cheapest Price
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