Ispinesib
- CasNo:336113-53-2
Product Description
Manufacturers supply cost-effective and customizable Ispinesib 336113-53-2 We supply high quality Ispinesib (CAS 336113-53-2), in stock, factory directly supply to clients, lower prices, more competitiveness.
What is the Ispinesib ?
Ispinesib is , while it's Molecular Formula is C30 H33 ClN4 O2 . The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells. Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2.3 nM) with >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins. It induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death (GI50s = 22-82 nM in colon, pancreas, prostrate, and lung cancer cells in vitro). At 10 mg/kg, ispinesib produces tumor regression of breast cancer cell xenografts in mice. It has also been used to halt the growth of treatment-resistant glioblastoma tumor-initiating cells, to prevent tumor initiation and self-renewal of a cancer stem cell population (EC50 = 1.15 nM), and to reduce glioma cell invasion.[Cayman Chemical]
What is the CAS number for Ispinesib ?
The CAS number of Ispinesib is 336113-53-2.
More information of Ispinesib 336113-53-2 are:
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Synonyms |
Ispinesib;SB 715992;(R)-N-(3-Aminopropyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl]-4-methylbenzamide; |
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CAS?Number |
336113-53-2 |
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Molecular Formula |
C30 H33 ClN4 O2 |
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Molecular Weight |
517.071 |
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Density |
1.216 g/cm3 |
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Boiling Point |
707.986 °C at 760 mmHg |
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Flash Point |
381.976 °C |
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PSA |
81.22000 |
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LogP |
6.29520 |
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Pka |
9.65±0.10(Predicted) |
What is Ispinesib (336113-53-2) used for?
Ispinesib is a potent and highly specific small-molecule inhibitor of kinesin-like spindle protein (KSP), which plays a crucial role in the formation of bipolar spindles during mitosis in both normal and tumor cells. It is an anticancer agent that has been tested for the treatment of human diseases.
InChI:InChI=1/C30H33ClN4O2/c1-20(2)27(34(17-7-16-32)29(36)23-12-10-21(3)11-13-23)28-33-26-18-24(31)14-15-25(26)30(37)35(28)19-22-8-5-4-6-9-22/h4-6,8-15,18,20,27H,7,16-17,19,32H2,1-3H3/t27-/m1/s1
Articles related to Ispinesib:
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Article |
Source |
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Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression |
Holland, Jason P.,Jones, Michael W.,Cohrs, Susan,Schibli, Roger,Fischer, Eliane supporting information, p. 496 - 507 (2013/03/13) |
How to get the best price on Ispinesib?
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