7-bromo-2,4,8,9-tetrazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine
- CasNo:83255-86-1
Product Description
7-bromo-2,4,8,9-tetrazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine 83255-86-1 with purity >99% Low price in stock
- Molecular Formula:C5H4BrN5
- Molecular Weight:214.024
- Melting Point:350°C(lit.)
- Refractive Index:1.851
- Boiling Point:287.4±50.0 °C(Predicted)
- PKA:10.32±0.20(Predicted)
- PSA：80.48000
- Density:2.14 g/cm3
- LogP:1.27880
7-bromo-2,4,8,9-tetrazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine(Cas 83255-86-1) Usage
InChI:InChI=1/C5H4BrN5/c6-3-2-4(7)8-1-9-5(2)11-10-3/h1H,(H3,7,8,9,10,11)
83255-86-1 Relevant articles
Revisiting Pyrazolo[3,4- d]pyrimidine Nucleosides as Anti- Trypanosoma cruzi and Antileishmanial Agents
Bouton, Jakob,Ferreira De Almeida Fiuza, Ludmila,Cardoso Santos, Camila,Mazzarella, Maria Angela,De Nazaré Correia Soeiro, Maria,Maes, Louis,Karalic, Izet,Caljon, Guy,Van Calenbergh, Serge
, p. 4206 - 4238 (2021/05/04)
Chagas disease and visceral leishmaniasi...
CYCLOALKYLIDENE CARBOXYLIC ACIDS AND DERIVATIVES AS BTK INHIBITORS
-
Page/Page column 133, (2021/03/05)
The present invention relates to novel c...
Hydroxamic acid derivative containing pyrazolopyrimidine and preparation method and application thereof
-
Paragraph 0093; 0112; 0113, (2020/09/23)
The invention provides a hydroxamic acid...
Design and synthesis of novel 1-substituted 3-(6-phenoxypyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine analogs as selective BTK inhibitors for the treatment of mantle cell lymphoma
Ran, Fansheng,Liu, Yang,Yu, Shengping,Guo, Kaiwen,Tang, Wendi,Chen, Xin,Zhao, Guisen
, (2019/11/11)
Ibrutinib (IBN), a first-in-class BTK-in...
83255-86-1 Process route
-
-
2380-63-4
4-Aminopyrazolo<3,4-d>pyrimidin
-
-
83255-86-1
3-bromo-4-aminopyrazolo<3,4-d>pyrimidine
| Conditions | Yield |
|---|---|
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 3h;
|
100% |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 5h;
|
92% |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 60 ℃;
|
91% |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 90 ℃;
for 1h;
|
84% |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 20 - 65 ℃;
for 4h;
|
82% |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 3h;
|
79.9% |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 3h;
|
79.9% |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 80 ℃;
|
79.9% |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 2.5h;
|
72% |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 8h;
|
64.4% |
|
With
N-Bromosuccinimide; N,N-dimethyl-formamide;
at 80 ℃;
for 8h;
|
64% |
|
With
bromine;
In
water;
1. 20 deg C, 1 h; 2. 100 deg C, 1 h;
|
50% |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 4h;
|
|
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
Inert atmosphere;
|
|
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 4h;
|
27.9 g |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 4h;
|
27.9 g |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 60 ℃;
Inert atmosphere;
|
|
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 5h;
|
|
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 60 ℃;
Inert atmosphere;
|
|
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 2h;
|
|
|
4-Aminopyrazolo<3,4-d>pyrimidin;
With
N,N-dimethyl-formamide;
In
thionyl chloride;
at 20 ℃;
for 1h;
With
bromine;
In
thionyl chloride;
at 60 ℃;
for 3h;
|
|
|
With
bromine;
In
water;
at 20 ℃;
for 2h;
Reflux;
|
2.5 g |
|
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 70 - 80 ℃;
for 3h;
|
560 g |
-
-
90914-41-3
3-bromo-4-chloropyrazolo<3,4-d>pyrimidine
-
-
83255-86-1
3-bromo-4-aminopyrazolo<3,4-d>pyrimidine
| Conditions | Yield |
|---|---|
|
With
ammonium hydroxide;
In
isopropyl alcohol;
at 95 ℃;
|
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-
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3-bromo-4-chloropyrazolo<3,4-d>pyrimidine
83255-86-1 Downstream products
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-
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-
1419223-03-2
(R)-4-(4-amino-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide
-
1224844-38-5
INK128